I regret to say that I had never heard of the Sudd Swamp. This is a:

vast swamp in South Sudan, formed by the White Nile‘s Baḥr al-Jabal section. The Arabic word sudd is derived from sadd, meaning “barrier” or “obstruction”. The term “the sudd” has come to refer to any large solid floating vegetation island or mat. The area which the swamp covers is one of the world’s largest wetlands and the largest freshwater wetland in the Nile basin.

For many years the swamp, and especially its thicket of vegetation, proved an impenetrable barrier to navigation along the Nile. The ancient Egyptians failed to penetrate the Sudd and reach the areas south of it. In AD 61, a party of Roman soldiers sent by the Emperor Nero proceeded up the White Nile but were not able to get beyond the Sudd, which marked the limit of Roman penetration into equatorial Africa. For the same reasons in later times, the search for the source of the Nile was particularly difficult; it eventually involved overland expeditions from the central African coast, so as to avoid having to travel through the Sudd.

More at Wikipedia. It seems that it formed as much of a barrier between the Mediterranean world and the rest of Africa as the Sahara desert did.